| beehive: histamine sequestered inside the granules of mast cells | … |
| ‘Q’ dandelion: H1 histamine receptor is coupled to Gq protein (mediates allergic inflammation) | … |
| honeypot with 2 ‘S’ handles: H2 histamine receptor is coupled to Gs protein | … |
| golden gastric honey: H2 histamine receptor mediates gastric acid secretion | … |
| dripping nose sap: histamine increases nasal and bronchial mucus production (H1 receptor activation) | … |
| dripping vascular sap: histamine increases vascular permeability (H1 receptor activation) –> urticaria or hives | … |
| constricted lung branch: histamine causes constriction of bronchial smooth muscle (H1 receptor activation) | … |
| brain tree: histamine functions as a neurotransmitter from non-mast cell (H1 receptor regulates sleep and arousal and neuroendocrine regulation) | … |
| bee swatter: H1 receptor blocker (antihistamine) treats allergy | … |
| dragonfly fairy: diphenhydramine and dimenhydrinate (1st generation H1 receptor blocker) | … |
| color fairy: chlorpheniramine (1st generation H1 receptor blocker) | … |
| fairy cuiSINE: hydroxyZINE, mecliZINE, promethaZINE (1st generation H1 receptor blockers) | … |
| fairy dust and dander: histamine mediates type-1 allergic reaction –> hives, allergic rhinitis (H1 receptor blockers are first line therapy) | … |
| seasick fairy sailors: 1st-generation H1-blockers treat vestibular nausea or motion sickness (lipophilic –> enter CNS –> act on vestibular system and brainstem) | … |
| current by the brain: 1st gen H1 receptor blockers easily cross bbb | … |
| sleeping under brain tree: 1st gen H1 blockers cause drowsiness by interfering with histamine neurotransmission (lipophilic –> cross BBB–> central effects), e.g. diphenhydramine can be used to treat insomnia | … |
| antimuscarinic tea party: 1st generation H1 blockers antagonize peripheral and central muscarinic receptors (e.g. pupillary dilation, dry mouth, urinary retention, constipation, exacerbation of glaucoma, and delirium) | … |
| falling “extra parking” cone: 1st-generation H1-blockers treat extrapyramidal side effects caused by antipsychotics, e.g. acute dystonia (antimuscarinic effects re-establish dopaminergic cholinergic balance) | … |
| cut smiley face cake: 1st gen H1 blockers antagonize serotonin receptors in the CNS | … |
| Stuffed fairy: 1st-gen H1 blockers stimulate appetite and weight gain (anti- serotonergic effects)fainted fairy: 1st gen H1 blockers cause dizziness and hypotension (anti-alpha-adrenergic effects) | … |
| extinguished single alpha candle: 1st-gen H1- blockers antagonize alpha-1 receptor –> dizziness and hypotension | … |
| delirious elderly man: 1st gen H1 blockers cause cognitive impairment in the elderly (central antihistamine and antimuscarinic effects) | … |
| fox, satyr, and rat: 2nd-gen H1 blockers, fexofenadine, cetirizine, loratidine | … |
| fox, satyr, and rat stand outside of brain tree: 2nd gen H1 blockers are less lipophilic –> do not cross BBB –> less sedating (also less antimuscarinic, antiserotonergic, or anti-alpha adrenergic properties)treat allergic rhinits and urticaria for minimal side effects | … |
Sketchy pharm: a midsummer night’s diphenhydramine (H1 receptor antagonists
August 29, 2019